Altered purinergic signaling in colorectal dorsal root ganglion neurons 1 contributes to colorectal hypersensitivity 2 3
نویسندگان
چکیده
Altered purinergic signaling in colorectal dorsal root ganglion neurons 1 contributes to colorectal hypersensitivity 2 3 Masamichi Shinoda, Jun-Ho La, Klaus Bielefeldt, G. F. Gebhart 4 Center for Pain Research, Departments of Anesthesiology and Medicine, 5 School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213 6 7 Running title; P2X3 receptors contribute to colon hypersensitivity 8 The number of text pages of the entire manuscript; 36 9 The number of figures and tables; 14 10 Keywords; Irritable bowel syndrome, colon hypersensitivity, ATP, P2X3 receptor 11 12 Correspondence: 13 Masamichi Shinoda, D.D.S., Ph.D 14 Assistant Professor 15 Department of Physiology, Nihon University School of Dentistry 16 1-8-13 Kandasurugadai, Chiyoda-ku,Tokyo 101-8310, Japan. 17 e-mail; [email protected] 18 Tel.;+81-3-3219-8122 19 Fax;+81-3-3219-8341 20 Articles in PresS. J Neurophysiol (September 22, 2010). doi:10.1152/jn.00560.2010
منابع مشابه
Altered purinergic signaling in colorectal dorsal root ganglion neurons contributes to colorectal hypersensitivity.
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by pain and hypersensitivity in the relative absence of colon inflammation or structural changes. To assess the role of P2X receptors expressed in colorectal dorsal root ganglion (c-DRG) neurons and colon hypersensitivity, we studied excitability and purinergic signaling of retrogradely labeled mouse thoracol...
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